Google了一下, 在NCBI看到關於downsteam promoter的文章.\"The downstream promoter element (DPE) functions cooperatively with the initiator (Inr) for the binding of TFIID in the transcription of core promoters in the absence of a TATA box.\"(Kutach, 2000)這樣說來,可以解釋為甚麼mutation on TATA-box並不影響基因的transcription. 文章裡面說決定transcription的是DPE和Inr之間的space.所以deletion和insertion會使RNA pol的binding property下降,導致reduction of transcription. 連接post出來給各位研究:http://www.ncbi.nlm.nih.gov/entr ... ;list_uids=10848601